3D-BrAIn Project

Revolutionizing personalised precision medicine
for central nervous system disorders

The Project

3D-BrAIn is an EU-funded research project aimed at developing personalised precision medicine for central nervous system (CNS) disorders. The project will combine stem cells technology, advanced microelectrode array recording, and artificial intelligence (AI)-based data analysis to create an innovative bio-digital twin model of the human brain that is personalized, precise, and predictive. The resulting 3D-BrAIn platform will allow robust and accurate modelling of the human frontal cortex to support the development of personalized medicine, drug screening, and neurotoxicity testing across a broad range of neuropsychiatric diseases.




EU Countries





Million € in EU Funding


Work Packages

Why 3D-BrAIn

Central nervous system (CNS) disorders are a large group of conditions that affect the brain, such as Alzheimer’s disease, epilepsy, autism, and schizophrenia. These disorders are a leading cause of disability and death worldwide, with an estimated one billion people affected globally. The treatment of CNS disorders can be challenging, as the brain is a complex organ with billions of neurons and trillions of synapses, and patients may have varying symptoms and disease progression. Treatment options vary depending on the disorder and can include medications, physical therapy, and surgery. However, these approaches lack precision, and there is a growing interest in personalized precision medicine to improve treatment effectiveness and reduce side effects.

Personalized precision medicine refers to tailoring treatments to an individual’s specific genetic, molecular, and clinical characteristics, and it represents a promising new area of treatment for CNS disorders. This approach recognizes that individuals with CNS disorders can differ significantly in terms of their symptoms, disease progression, and response to treatment. To achieve this, researchers are developing physiologically representative models of the CNS to investigate disease mechanisms and test new therapies. These models can simulate the complex structure and function of the CNS, allowing researchers to investigate how CNS disorders develop and progress and to identify potential targets for new therapies.

The 3D-BrAIn project is a research initiative aimed at developing a bio-digital twin model of the human brain that is personalized, precise, and predictive. The goal is to develop a platform that can be used to develop personalized treatment plans for patients with CNS disorders, improving treatment outcomes and reducing the burden of these conditions on individuals and society. The project aims to have this technology ready within the next 5 years (2028), and it has the potential to revolutionize personalized precision medicine for CNS disorders.