Femke de Vrij
Introducing Femke de Vrij
Femke de Vrij received her MSc degree in Medical Biology from the University of Utrecht in 1999. As a PhD student, she worked on the molecular basis of Alzheimer’s disease at the Netherlands Institute for Neuroscience (NIN) in Amsterdam and received her PhD from the University of Amsterdam in 2005. After a postdoc at the department of Clinical Genetics of Erasmus MC, working on the neurobiology of Fragile X syndrome, she joined the Neurobiological Psychiatry group in February 2010 where she now has her own lab on human disease models of neuropsychiatric disorders.
Femke de Vrij
Principal investigator and
Project leader 3D-BrAIn
Key Publications
- De Vrij FMS, Bouwkamp CG, Gunhanlar N, et al. Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia. Molecular Psychiatry. 2019; 24(5): 757-771.
- Gunhanlar N, Shpak G, van der Kroeg M, Gouty-Colomer LA, Munshi ST, Lendemeijer B, Ghazvini M, Dupont C, Hoogendijk WJG, Gribnau J, De Vrij FMS*, Kushner SA*. A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells. Molecular Psychiatry 2017: 1–9.
- Van Esbroeck ACM, Janssen APA, Cognetta AB, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, De Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, Van der Wel T, Soethoudt M, Mock ED, Den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner, SA, Van der Stelt, M. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science 2017; 356: 1084–1087.
