Huge congratulations to our team members Silvia Cappello, Rebecca Bonrath, Femke de Vrij, Steven A. Kushnerand and their colleagues for their collaboration in this latest publication in Nature Communications! 

This study explores gray matter heterotopia—with a focus on its common form, periventricular heterotopia—a brain developmental disorder linked to drug-resistant seizures and cognitive challenges, though its causes remain largely unclear.

By using human cerebral organoids derived from patients with mutations in FAT4 or DCHS1, the team was able to replicate periventricular heterotopia brain activity, revealing hyperactive neuronal networks and structural changes in neurons, as well as alterations in synaptic function. This led to ground-breaking insights into the cellular changes underlying gray matter heterotopia symptoms!

Read the full study 👉 https://www.nature.com/articles/s41467-025-56998-1#author-information